2015 Summer at Stanford University

Stanford, CA
To explore the causes and roots of cancer development, I compared the differences between cancer tissue and control normal tissue. Two ways I did this were by comparing cancer and normal tissue by examining differences in the genome and gene expression profile.

By looking at the genome of a tissue, I examined both the genes and non-coding DNA, and more. Through this, I examined what a cell’s sequence could possibly do. By looking at the gene expression profile, I examined the functionality of the genome (what genes were being transcribed into RNA) and what a cell’s sequence was actually doing at a point in time. Technology like next-generation high-throughput sequencing (NGS) facilitated this work and allowed the parallelization of DNA and RNA sequencing to greatly increase the number of sequences read each run.